JAMA

ObjectiveTo examine racial and ethnic inequities in wealth and health among New York City adults. MethodsWe conducted the 2024 NYC Racial Wealth and Health Gap Survey using a stratified quota sample of 2,866 adults across 11 racial and ethnic groups. Wealth was measured through self-reported assets and debts, and health through self-reported status and psychological distress. We calculated descriptive statistics across groups and used quantile regression to test for significant differences in a...

ObjectiveTo evaluate the impact of a comprehensive behavioral health (BH) program on healthcare utilization and total medical spending across 17 employer health plans. Study Setting and DesignA retrospective evaluation of benefit implementation across 17 employer-sponsored health plans between November 1, 2019, and January 1, 2025. Interrupted time series analysis models were used to estimate shifts in utilization patterns and medical spending across the entire health plan population before and...

BackgroundSymptom diaries are widely used in acute respiratory infection trials to capture patient-reported symptom severity and recovery. Longer questionnaires may provide a more complete clinical picture but can increase participant burden and reduce adherence. Evidence directly comparing long and short formats within the same trial is limited. ObjectiveTo compare adherence, symptom trajectories, agreement between recovery measures, and predictive performance for recovery-related outcomes bet...

Frequent blood testing is a routine but burdensome reality for many children, particularly those with chronic, rare, or medically complex conditions. Repeated clinic, hospital, and laboratory visits can disrupt family life, increase stress for children and caregivers, and limit access to timely monitoring and research participation. Despite advances in pediatric care, blood collection has remained largely tethered to in-person clinical settings. This study validates a new model: safe, effective,...

PuhrposeTo evaluate the short- and long-term cross-sectional associations between COVID-19 infection and multidimensional sleep health. MethodsData from the COVID-19 Outbreak Public Evaluation (COPE) initiative were used to examine the association between a novel multidimensional sleep health measure (COPE Multidimensional Sleep Health Scale, CMSHS) modeled from the RuSATED instrument and (1) COVID-19 infection and (2) post-acute sequelae of SARS-CoV-2 infection (PASC). ResultsData from 11,326...

BackgroundThe 340B Drug Pricing Program was established to expand access to care for low-income and uninsured patients by allowing safety-net hospitals and clinics to purchase outpatient drugs at discounted prices. Over time, the program has expanded substantially, raising questions about whether participating hospitals are meeting the programs intended objectives. MethodsUsing 2023 hospital financial data from the RAND Corporation, we conducted cross-sectional descriptive comparisons of 340B a...

BackgroundChronic cardiovascular diseases (CVD) care quality remains suboptimal, globally. This study evaluated the feasibility and preliminary effect of a multicomponent, collaborative quality improvement (C-QIP) strategy among patients with CVD attending outpatient clinics in India. Methods and FindingsWe conducted a pragmatic feasibility randomized controlled trial in patients with ischemic heart disease, ischemic stroke or heart failure across public and private hospitals in India. Particip...

BackgroundDelivering timely, high-quality feedback on resident scholarly projects is labour-intensive, especially in large programmes. We developed an AI-assisted evaluation system, powered by the open-weight LLaMA-3.1 large-language model (LLM), to generate formative feedback on Family Medicine residents scholarly projects and compared its performance with expert human evaluators. MethodsWe evaluated whether the AI-generated feedback achieves comparable quality to expert feedback. The tool ing...

BackgroundHypertension is a major modifiable risk factor for cardiovascular disease, yet blood pressure (BP) control remain suboptimal, particularly in socially disadvantaged communities. Guidelines recommend initiating single-pill combination (SPC) therapy to improve adherence and BP control, but uptake in primary care is limited. ObjectivesTo evaluate the SOLO care improvement project, promoting SPC initiation among general practitioners (GPs) in Amsterdam Zuidoost, a disadvantaged, multi-eth...

BackgroundTraditional, complementary, and integrative medicine (TCIM) describes a broad collection of medical interventions, practices, and belief systems that fall outside the purview of conventional medicine. Accompanying the recent growth of TCIM research productivity, artificial intelligence (AI) technologies have increasingly impacted areas of biomedical research, including diagnosis, treatment planning, and drug discovery. This bibliometric analysis explores the characteristics of research...

Allogeneic hematopoietic cell transplantation is the only curative option for many patients with acute myeloid leukemia (AML). In the current study, we designed and implemented a personalized assay, called v96, incorporating up to 96 mutations in 30 AML patients undergoing transplantation. The assay was performed on DNA derived in cells from the bone marrow as well as in cell-free plasma. All 30 (100%) of patients harbored molecular evidence of residual leukemia during remission that was detecta...

BackgroundMulti-system impacts of long COVID remain unknown. We compared multi-system deficits between people with long COVID and controls. MethodsA case-control study recruited from the Avon Longitudinal Study of Parents and Children and TwinsUK population cohorts. Cases (141) had long COVID (evidence of COVID-19 infection and persistent symptoms [&ge;]4 weeks post infection); controls (280) included people making a full recovery in <4 weeks, people self-reporting long COVID like symptoms but ...

BackgroundArtificial intelligence chatbots (AICs) are increasingly being integrated into scholarly publishing, with the potential to automate routine editorial tasks and streamline workflows. In traditional, complementary, and integrative medicine (TCIM) publishing, editorial and peer review processes can be particularly complex due to diverse methodologies and culturally embedded knowledge systems, presenting unique opportunities and challenges for AIC adoption. MethodsAn anonymous, online cro...

The growth of generative AI and easily available Open Access health datasets has transformed researcher productivity, leading to an explosion in publications that has in part been attributed to paper mills (organisations that provide manuscripts for payment) and other unethical actors. These entities are not, however, homogenous, and have a range of products and target markets. While the demand from China has received much attention, here we provide a case study of CDC WONDER, a dataset that has...

COVID-19 has been shown to cause a range of harmful long-term effects on nearly every organ system1-3. These findings are based on retrospective studies comparing COVID-19 patients to patients with similar medical histories and demographics but no COVID-19 diagnosis4-16. However, concerns have emerged that these comparisons may be biased if COVID-19 patients had unrelated health conditions or other factors not recorded in their medical records17-21. Here, using a massive dataset of 14.4 billion ...

ObjectiveTo characterize associations between tattooing and health status. MethodsWe used data from [~]27,000 respondents to the 2020-2022 Utah Behavioral Risk Factor Surveillance System (BRFSS). Multivariable Poisson regression was used to calculate prevalence ratios (PR) and 95% confidence intervals (CI) associating ever receiving a tattoo with physical/mental health status. ResultsIn this cross-sectional study, ever receiving a tattoo was associated with self-reported "poorer" vs. "excellen...

BackgroundEarly life social determinants of health, such as childhood trauma, have implication on adverse health outcomes later in the life course. Our objective was to develop a childhood trauma measure within the Health and Retirement Study (HRS) - a large, diverse, U.S.-based aging cohort. MethodsData from the HRS Psychosocial and Lifestyle Questionnaire [2006-2016] and Life History Survey [2015-2017]) surveys collected thirteen binary items measuring self-reported exposure to early life adv...

Artificial intelligence (AI) is increasingly positioned as a transformative tool in education and health. Yet empirical evidence on AI readiness in low-and middle-income countries, particularly among youth, remains scarce. This study examined patterns of adoption, equity determinants, and ethical awareness among Ghanaian youth to inform responsible AI integration in education and health systems. A cross-sectional survey was conducted among 200 youth aged 18-35 years in Ghana. Descriptive statist...

PurposeThe COVID-19 pandemic has had profound and multifaceted impacts on children and adolescents, exposing and deepening pre-existing inequalities while creating unique health, social, and educational challenges. In response to the limited evidence-based knowledge available, the SEROCoV-KIDS study was launched in 2021 as a prospective cohort and biobank to assess the pandemics effects on youth health and well-being. It focuses on the general population of Geneva, Switzerland, as well as subgro...

Relapsed and/or refractory disease remains the leading cause of death in AML, highlighting the need for broadly applicable, high-sensitivity approaches to MRD detection. We developed AML-CAPP-Seq (Cancer Personalized Profiling by Deep Sequencing), a personalized hybrid-capture assay that tracks both canonical AML drivers and patient-specific variants identified by whole-exome sequencing. In 56 patients with longitudinal plasma and matched peripheral blood and bone marrow samples, AML-CAPP-Seq en...