Vitamin D supplementation on colorectal cancer incidence and mortality:a meta-analysis of randomized controlled clinical trials and trial sequential analysis
Fu, D.; Yang, W.; Li, Y.
Show abstract
ObjectiveTo evaluate the effect of oral vitamin D supplementation on colorectal cancer incidence and mortality. MethodsAll randomized controlled trials regarding effect of oral vitamin D on colorectal cancer from PubMed, Web of science, Embase and Cochrane Library were searched. Meta analysis and trial sequential analysis of included studies were carried out. ResultsSeven RCTs enrolling 72810 participants were included. Compared with placebo, oral vitamin D supplementation was not associated with the incidence of colorectal cancer(RR=1.1,95%CI:0.93-1.31;p=0.28).Subgroup analysis showed no difference in female participants for incidence of colorectal cancer(RR=1.04,95% CI:0.84-1.28;p=0.73). The pooled RR, included 41643 participants, showed no difference in mortality of colorectal cancer(RR= 0.82, 95% CI:0.56 to 1.21; p = 0.32). Trial sequential analysis showed the z-line did not cross the conventional test boundary, TSA monitoring boundary and futility boundaries. ConclusionOral vitamin D supplementation offers no benefit on the incidence and mortality of colorectal cancer. However, the RCTs with longer follow-up are needed to ascertain the efficacy of Vitamin D, especially among adults with lower serum 25(OH)D levels in future.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Erroneous risks in pharmaceutical versus non-pharmaceutical interventions during data extraction in evidence synthesis practice: Study protocol for a randomized controlled trial 93%
- A Retrospective Analysis of Serious Adverse Events and Deaths in US-Based Lifestyle Clinical Trials for Cognitive Health 92%
- Plant Formulation ATRICOV 452 in Improving the Level of COVID-19 Specific Inflammatory Markers in Patients 89%
Similar papers in this journal
- Oral aspirin for preventing colorectal adenoma recurrence: a systematic review and network meta-analysis of randomized controlled trials 95%
- Relevance of Mediterranean diet as a nutritional strategy in diminishing COVID-19 risk: A systematic review 95%
- Efficacy of Acupuncture on Lower Limb Motor Dysfunction Following Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 94%
Similar papers in this journal
- p16 Expression and its correlation with the clinical pathological characteristics of cervical cancer patients: a systematic review and meta-Analysis 94%
- Efficacy and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in overweight/obese patients with or without diabetes mellitus: a systematic review and network meta-analysis 94%
- Efficacy and safety of acupuncture for postpartum hypogalactia: Protocol for a systematic review and meta-analysis 93%
Similar papers in this journal
- Methodological quality of recommendations on vitamin D and calcium – a systematic review of bone health guidelines 94%
- Are probiotics and prebiotics safe for use during pregnancy and lactation? A systematic review and meta-analysis 92%
- Efficacy and Safety of Habitual Consumption of a Food Supplement Containing Miraculin in Malnourished Cancer Patients: the CLINMIR Pilot Study 92%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.