F1000Research

ImportanceAnterior chamber paracentesis (ACP) is a known method of rapid reduction of IOP. The mechanism of how corneal fluid clears after ACP is not well described. ObjectiveTo determine the mechanism of instantaneous corneal clearing of edema after ACP. Design, setting, and participantsThis case series includes consecutive patients with high IOP and associated corneal edema, who presented to the Glaucoma Services of our tertiary care center. Pre- and post-intervention (ACP) ASOCTs were analy...

BackgroundThis systematic review and meta-analysis aim to evaluate the efficacy and safety of the PAUL(R) Glaucoma Implant in reducing intraocular pressure and number of anti-glaucoma medication use in both adult and paediatric populations. MethodsA systematic review was conducted following the PRISMA guidelines. The databases PubMed, Ovid-Embase and Scopus were searched to include studies published between January 2017 and September 2025. Studies were stratified by age and risk of bias was ass...

Structured AbstractO_ST_ABSPurposeC_ST_ABSThis systematic review investigates the current landscape of rheometric techniques used to study the viscosity and viscoelastic properties of vitreous humor to better understand vitreous behavior for clinical applications, particularly in anomalous posterior vitreous detachment (PVD). MethodsA comprehensive literature search was conducted in PubMed, EMBASE, and Scopus using the keywords "vitreous body," "viscosity," and "rheology." The review followed P...

PurposeTo evaluate anterior segment optical coherence tomography (AS-OCT) parameters of bleb wall thickness (BWT) and total bleb height (TBH) in the early postoperative phase after Preserflo Microshunt (PM) implantation for their correlation to (a) surgical revision and (b) AS-OCT angiography (AS-OCTA) derived bleb vessel density (BVD). MethodsA total of 23 patients with pharmacologically uncontrolled open angle glaucoma were studied. Post-operatively (at 1, 2, and 4 weeks and 2, 3, 6, 9, and 1...

AimsComparison of the efficacy of six Anti- vascular endothelial growth drugs in the treatment of diabetic macular edema MethodsThis network meta-analysis has been registered on the PROSPERO platform (CRD42022295684).A comprehensive search of eight databases without language restrictions.PubMed, EMBASE, Web of Science, Cochrane Library, CBM, CNKI, VIP, and Wanfang were used to search for randomized controlled trials on anti- vascular endothelial growth factor of diabetic macular edema, no langu...

BackgroundDry eye disease (DED) is a common chronic ocular disorder associated with ocular discomfort and tear film damage. Traditional medicinal uses of Diospyros kaki leaves have been well-documented for their potent radical-scavenging, antioxidant, and immune-modulatory properties. Emerging evidence suggests that D. kaki leaves can improve various ocular conditions, including dry eye disease and elevated intraocular pressure (IOP), making it a potential therapeutic option for managing these c...

ObjectiveTo assess visible aerosol generation during simulated vitrectomy surgery. Methods: A model comprising a human cadaveric corneoscleral rim mounted on an artificial anterior chamber was used. Three-port 25 gauge vitrectomy simulated surgery was performed with any visible aerosol production recorded using high speed 4K camera. The following were assessed: (1) vitrector at maximum cut rate in static and dynamic conditions inside the model, (2) vitrector at air-fluid interface in physical mo...

PO_SCPLOWURPOSEC_SCPLOW To quantify the effect of negative pressure applied to the anterior surface of the eye on absolute IOP. SO_SCPLOWUBJECTSC_SCPLOWParticipants, and/or Controls. Three eyes from three research-consented brain-dead organ donors. MO_SCPLOWETHODSC_SCPLOWAir-tight goggles connected to a negative pressure (NP) pump (Mercury Multi-pressure Dial (MPD); Equinox Ophthalmic, Inc., CA) were tested on three research consented brain-dead organ donors. The MPD was set to generate a vac...

PurposeTo achieve a highly balanced comparison of trabecular bypass stenting (IS2, iStent inject)with ab interno trabeculectomy (T, Trabectome) by exact matching. In a similar study, IS1 (1st generation iStent) had shown a loss of effect at 6 months. Methods53 IS2 eyes were matched to 3446 T eyes. Patients were matched using exact matching by baseline IOP, the number of glaucoma medications, and glaucoma type and using nearest neighbor matching by age. Individuals without a close match were exc...

ImportanceRetinal ganglion cells endure significant metabolic stress in glaucoma but maintain capacity to recover function. Nicotinamide, a precursor of NAD+, is low in serum of glaucoma patients and its supplementation provides robust protection of retinal ganglion cells in preclinical models. However, the potential of nicotinamide in human glaucoma is unknown. BackgroundTo determine whether nicotinamide supplementation alongside conventional IOP-lowering therapy improves retinal ganglion cell...

PurposeTo evaluate the three-year efficacy and safety of compound trabeculectomy for uveitic glaucoma (UG). MethodsThis retrospective study enrolled 51 patients (53 eyes) requiring compound trabeculectomy, divided into UG (25 eyes) and non-UG groups (28 eyes). Outcomes including intraocular pressure (IOP), medication use, surgical success rates, and complications were analyzed over 3 years. ResultsBaseline characteristics including age, sex, preoperative IOP and medication use were comparable ...

PurposeEvaluated the safety and efficacy of an integrative surgical approach to neovascular glaucoma (NVG). MethodsConsecutive interventional case series of NVG with one-year follow-up. Eyes underwent pars plana vitrectomy, near-confluent panretinal photocoagulation, intravitreal bevacizumab, and transscleral cyclophotocoagulation. Phakic eyes underwent concomitant cataract surgery. Best-corrected visual acuity (BCVA, logMAR), intraocular pressure (IOP, mmHg), glaucoma medication score (GMS), v...

PurposeTo compare the efficacy of Ex-PRESS implantation to trabeculectomy with mitomycin C, for maintaining low target intraocular pressure (IOP) in patients with open angle glaucoma. Materials and MethodsPatients were randomly assigned to receive Ex-PRESS implantation or trabeculectomy. Patients with IOP [≥] 15 mmHg were included in this study. Surgical success was defined according to three target mean IOP ranges (5 mmHg [≤] IOP [≤]18 mmHg [criterion A], 5 mmHg [≤] IOP [≤]15 mm...

PurposeTo evaluate if an intraoperative OCT (iOCT) optimized surgical protocol without prolonged overpressure is non-inferior to a standard protocol during Descemet membrane endothelial keratoplasty (DMEK). DesignA multicenter international prospective non-inferiority randomized control trial SubjectsSixty-five pseudophakic eyes of 65 patients with corneal endothelial dysfunction resulting from Fuchs endothelial corneal dystrophy were enrolled in 3 corneal centers in The Netherlands and Belgiu...

PurposeEvaluating 12-month visual and anatomical outcomes after switching to faricimab in diabetic macular oedema (DMO) patients with sub-optimal response to aflibercept 2mg. Patients and methodsSixty-two eyes of fifty patients were enrolled in this retrospective study at a UK tertiary referral centre. This consisted of DMO patients with sub-optimal response to aflibercept 2mg who were switched to faricimab. Four loading injections of faricimab were given at monthly intervals, followed by a tre...

BackgroundGlaucoma is a progressive optic neuropathy primarily associated with elevated intraocular pressure (IOP) and characterized by optic nerve damage. Despite numerous risk factors, including high IOP, the molecular mechanisms underlying glaucoma remain unclear. The cathepsin family, a group of lysosomal proteases, plays a critical role in various physiological and pathological processes. This study investigates the causal relationship between cathepsins and glaucoma using Mendelian Randomi...

PurposeThis study aims to evaluate the average motility of the implant and custom-made prosthesis after MES, the surgical duration, and the complications encountered during the procedure at a tertiary eye hospital. MethodsThis was a prospective, non-randomized interventional study. The muscles were sutured to the fornices before the enucleation of the eyeball to minimize surgical time and the need for additional sutures. 35 consecutive patients meeting the inclusion criteria were enrolled in th...

AimsTo evaluate the effect of toric intraocular lens implantation in cataract patient with corneal opacity and high astigmatism. Methods31 eyes of 31 patients who underwent cataract surgery with toric intraocular lens implantation were included. All patients had corneal opacity with regular astigmatism. Preoperative total corneal astigmatism was determined considering posterior astigmatism using a rotating Scheimpflug camera (Pentacam(R): Oculus, Wetzlar, Germany). At 2 months after toric intra...

ObjectiveTo assess potential methods of reducing visible aerosol generation during clear corneal phacoemulsification surgery in the era of Covid-19. MethodsAerosol generation during phacoemulsification was assessed using a model comprising a human cadaveric corneoscleral rim mounted on an artificial anterior chamber. Typical phacoemulsification settings were used and visible aerosol production was recorded using high speed 4K camera. Aerosolisation was evaluated under various experimental setti...

ObjectivesThis prospective study aims to evaluate the outcomes and safety of Ultrasound Cycloplasty(UCP) in controlling intraocular pressure in patients with prior failed glaucoma surgeries. MethodsA total of 20 eyes from 19 patients who underwent UCP following failed glaucoma surgery between September 2020 to September 2022, were included. All patients were followed for over 12 months. Intraocular pressure, ocular hypotensive medications, and best-corrected visual acuity were recorded and comp...