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Thiamine alone rather than in combination with ascorbic acid is associated with improved survival in septic shock.

2023-04-17 intensive care and critical care medicine Title + abstract only
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BackgroundSepsis and septic shock are common causes of ICU admission with devastating outcomes. Adjunctive therapies are urgently needed, and the use of high dose of vitamin B1 and C have recently gained interest. However, on the basis of a perceived possible synergic effect, most trials have never tested the combination of thiamine and ascorbic acid, with a separate assessment of the effect of each individual component. In this context, while the association of thiamine and ascorbic acid was no...

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