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The Prevention and Control of Cancer by Metformin in Patients with Type 2 Diabetes: A Systematic Mapping Review

Cipriano, G.; Mitchell, A.; Price, M.

2021-06-05 endocrinology
10.1101/2021.06.04.21258310 medRxiv
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ObjectiveMetformin is commonly used as a first line therapy for type 2 diabetes; however, existing evidence suggests an influence in oncology. The objective of this systematic mapping review was to describe current literature regarding metformin and its role in preventing and /or controlling cancer in patients with type 2 diabetes. MethodWe searched PubMed, Cochrane Library, and ClinicalTrials.gov in February 2018 and April 2019 to identify research studies, systematic reviews and meta-analyses. Of the 318 citations identified, 156 publications were included in this analysis. ResultsThe most common cancer types researched were colorectal, liver, prostate, lung and breast with the United States contributing the most to this data. Author teams averaged six members and most studies were funded. Only 68% of the articles were available open access. Ovarian and esophageal cancers were amongst the least studied, but the most costly for care.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.