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Metabolic Adaptations to Long-Term Caloric Restriction: Principal Components Analysis of Mass-Spectrometry Metabolomics from the CALERIE™ Phase 2 Trial
2026-02-24
nutrition
Title + abstract only
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BackgroundCaloric restriction (CR) improves markers of biological aging, yet long-term effects on the human metabolome remain unclear. ObjectiveThis study examined the effects of CR (2 years) in healthy adults without obesity on circulating metabolites linked to aging and metabolic adaptations. MethodsUntargeted metabolomics was performed using fasted plasma samples collected at baseline, 12, and 24 months (BL, 12M, 24M) from CALERIE participants randomized to CR or ad libitum (AL) control. A ...
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