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Associations of Epigenetic Age Acceleration with Motor Impairment: Evidence from the PPMI Cohort
2025-12-17
neurology
Title + abstract only
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ObjectiveMotor decline is a hallmark of Parkinsons disease (PD) and biological aging. While epigenetic clocks measure systemic biological aging, their specific relationship with neuromotor function in the context of aging and neurodegeneration remains under-characterized. This study utilized data from the Parkinsons Progression Markers Initiative (PPMI) to examine the relationships between multiple DNA methylation-based epigenetic aging measures and motor impairment across distinct domains. Met...
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