Fecal Microbiota Transplantation Decreases Amyloid Load and Improves Cognition in Alzheimer’s
Elangovan, S.; Borody, T. J.; Holsinger, R. M. D.
Show abstract
The efficacy of fecal microbiota transplantation (FMT) in Alzheimers disease has yet to be investigated. Here, we show that FMT is capable of providing neuroprotective effects in two groups of treated 5xFAD Alzheimers mice, old transgenic (Tg) mice fed fecal slurry from healthy, wild-type donors of similar age (Old Tg-FO) and old mice fed fecal slurry from younger healthy, wild-type donors (Old Tg-FY). Improved spatial and recognition memory in Old Tg-FY and enhanced recognition memory in Old Tg-FO were observed when compared to Old Tg-Control mice given saline. Crucially, there was significant decreases in cortical A{beta} loading in all treated mice, demonstrating the therapeutic effects of FMT in improving cognition and reducing amyloid pathology in AD brains.\n\nOne Sentence SummaryFecal microbial transplants reduce amyloid pathology and improve cognition in Alzheimers mice.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Age-related changes in Tau and Autophagy in human brain in the absence of neurodegeneration 95%
- Voluntary running does not increase capillary blood flow but promotes neurogenesis and short-term memory in the APP/PS1 mouse model of Alzheimers disease 94%
- Protective mutation A673T as a potential gene therapy for most forms of APP Familial Alzheimer's Disease 93%
Similar papers in this journal
- D-Methionine Improves Spatial Navigation and Attenuates Oxidative Stress and Amyloid Pathology in a Sex-Specific Manner 94%
- Association of GLOD4 with Alzheimers Disease in Humans and Mice 94%
- Ketogenic Diet Enhances Cognitive-Behavioral Function and Hippocampal Neurogenesis While Attenuating Amyloid Pathology in Tg-SwDI Mice 94%
Similar papers in this journal
- Attenuated cognitive decline in community-dwelling older adults with higher plasma adropin concentrations 95%
- A Compound Enhancing Lysosomal Function Reduces Tau Pathology, Microglial Reactivity and Rescues Working Memory in 3xTg AD Mice 94%
- Increased Genetic Protection Against Alzheimer's Disease in Centenarians 94%
Similar papers in this journal
- Plcg2M28L interacts with high fat-high sugar diet to accelerate Alzheimers disease-relevant phenotypes in mice 94%
- Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice 94%
- Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome 94%
Similar papers in this journal
- A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease 95%
- Age, Sex and Alzheimer's disease: A longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer's patients 94%
- Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer’s disease 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.