Elevated serum aspartate aminotransferase levels concomitant with normal alanine aminotransferase levels in older low body weight people: Preliminary findings from a community-based epidemiological study
Shibata, M.; Nakajima, K.
Show abstract
BackgroundSerum enzyme levels, including hepatic transaminase, are unknown in older people with low body weight (LBW), who can easily experience sarcopenia. Therefore, we addressed preliminarily this issue in a cross-sectional study of an apparently healthy population. MethodsWe investigated the relationship of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and total bilirubin levels with body mass index (BMI) and age in 79,623 subjects aged 20-80 years who underwent an annual checkup. ResultsSerum levels of AST, ALP, and LDH levels were significantly higher in older ([≥]50 years) non-obese subjects compared with younger (< 50 years) corresponding subjects. Serum AST levels were significantly higher in older LBW subjects (BMI[≤]18.9 kg/m2) than in those with a reference BMI of 20.9-22.9 kg/m2. Serum AST levels showed a J-shaped curve against BMI, whereas ALT and GGT levels showed a linear relationship, regardless of age. ConclusionElevated serum AST levels concomitant with normal ALT levels, which might reflect systemic damage of skeletal muscle, may be prevalent in older LBW people. Further studies need to determine whether such a condition is equivalent to the etiology of sarcopenia.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Relationship of sociodemographic and lifestyle factors and diet habits with metabolic syndrome (MetS) in a multi-ethnic Asian population 95%
- Low handgrip strength is closely associated with anemia among adults: A cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES) 94%
- Estimation equation of limb lean soft tissue mass in Asian athletes using bioelectrical impedance analysis 94%
Similar papers in this journal
- Prevalence of Mental Health Disorders among Elderly Diabetics and Associated Risk Factors in Indonesia 93%
- Motor imagery training is beneficial for motor memory of upper and lower limb tasks in very old adults 93%
- Role Of Body Mass And Physical Activity In Autonomic Function Modulation On Post-COVID-19 Condition: An Observational Subanalysis Of Fit-COVID Study 92%
Similar papers in this journal
- Effect of MIND Diet Intervention on Cognitive Performance and Brain Structure in Healthy Obese Women: A Randomized Controlled Trial 94%
- Association of Muscle Strength to Body Composition Measures using DXA, D 3 Cr, and BIA in Collegiate Athletes 93%
- Global chemical modifications comparison of human plasma proteomes from two different age groups 92%
Similar papers in this journal
- The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: A prospective study in Japan 94%
- Predicting the risk of sarcopenia in elderly patients with patellar fracture: Development and assessment of a new predictive nomogram 92%
- Epidemiological Correlates of Overweight and Obesity in the Northern Cape Province, South Africa 92%
Similar papers in this journal
- American older adults in COVID-19 Times:Vulnerability types, aging attitudes and emotional responses 91%
- Protocol of a Study to Benchmark Occupational Health and Safety in Japan: W2S-Ohpm Study 91%
- Study Protocol and Rationale of “The UP Project”: Evaluating the Effectiveness of Active Breaks on Health Indicators in Desk-Based Workers 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.