Blood Proteomic Biomarkers indicate reduced system and tissue level inflammation responses to The GOTO Lifestyle Intervention in Older Adults
Bogaards, F.; Gehrmann, T.; Beekmam, M.; Lakenberg, N.; Suchiman, E.; Mueller, R.-U.; Deelen, J.; Lackmann, J.-W.; de Groot, L.; Reinders, M.; Antczak, P.; Slagboom, P.
Show abstract
The effects of lifestyle interventions on the blood metabolome and transcriptome are well studied, but the interplay between tissues is not well understood. In a multi-omics multi-tissue design we study how the serum proteome reflects health improvements in age-related deficits such as body composition, fat and glucose metabolism and low-grade inflammation in older adults undergoing a 13-week lifestyle intervention (GOTO trial). Significant intervention effects on the fasting blood proteome were observed in both sexes, with downregulated immune-related pathways, including the complement system, inflammation, cholesterol transport and coagulation. These findings associated with improved body composition and immune-metabolic health markers. In addition, we found that the intervention-induced changes in the transcriptome of muscle and subcutaneous adipose tissue (SAT) biopsies were correlated with changes of the corresponding circulating proteins. The most notable correlations were observed for proteins involved in inflammatory processes and corresponding gene expression in the SAT. Our findings emphasize the broad beneficial effects of moderate lifestyle interventions in older adults and how circulating proteins such as FN1, LGALS3BP and PRG4 reflect the immune-metabolic health benefits.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis 96%
- An integrative study of five biological clocks in somatic and mental health 95%
- Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins 95%
Similar papers in this journal
- Blood methylation pattern reflects epigenetic remodelling in adipose tissue after bariatric surgery 94%
- 1 H-NMR metabolomics-based surrogates to impute common clinical risk factors and endpoints 94%
- Cold exposure induces dynamic changes in circulating triacylglycerol species, which is dependent on intracellular lipolysis: a randomized cross-over trial 94%
Similar papers in this journal
- Molecular programming in utero modulates hepatic lipid metabolism and adult metabolic risk in obese mother offspring in a sex-specific manner 95%
- Composite trait Mendelian Randomization reveals distinct metabolic and lifestyle consequences of differences in body shape 94%
- Revealing grand-paternal programming of lipid metabolism using a novel computational tool 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.