Lysergic Acid Diethylamide extends lifespan in Caenorhabditis elegans
Carrilho, B. d. S.; Silva, A. D.; Sant Anna, A. M. K.; Ventura, M. A. V. d. C.; Moll, F. T.; Aguilaniu, H.; Domith, I.; Rehen, S. K.
Show abstract
Aging is modulated by nutrient-sensing pathways that integrate metabolic and hormonal cues to regulate growth, stress resilience, and lifespan. Caloric restriction (CR), a well-established intervention, extends longevity in diverse species primarily through inhibition of the TOR signaling pathway. Lysergic acid diethylamide (LSD), a classic serotonergic psychedelic with emerging therapeutic applications, remains largely unexplored in the context of aging. Here, we show that LSD treatment significantly extends lifespan in Caenorhabditis elegans and reduces age-associated lipofuscin accumulation, indicative of delayed cellular aging. LSD reproduces several CR-like phenotypes, including decreased reproductive output and increased nuclear localization of the transcription factor PHA-4/FOXA, without affecting food intake. Moreover, LSD treatment reduces lipid stores and downregulates global protein synthesis, both hallmark signatures of TOR inhibition. These findings establish LSD as a modulator of evolutionarily conserved longevity pathways and suggest that psychedelic signaling can mimic a caloric restriction-like metabolic state, paving the way for the development of novel geroprotective strategies.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes 96%
- Diets affect the age-dependent decline of associative learning in Caenorhabditis elegans 95%
- Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms 95%
Similar papers in this journal
- Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity 97%
- Neuroprotective effects of Canagliflozin: lessons from aged genetically diverse UM-HET3 mice. 95%
- Hexosamine pathway activation improves memory but does not extend lifespan in mice. 94%
Similar papers in this journal
- Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity 96%
- Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan 95%
- Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions 95%
Similar papers in this journal
- Reproductive tradeoffs govern sexually dimorphic tubular lysosome induction in C. elegans 95%
- Early-life hypoxia alters adult physiology and reduces stress resistance and lifespan in Drosophila 93%
- Drosophila larval epidermal cells only exhibit epidermal aging when they persist to the adult stage 93%
Similar papers in this journal
- Bacterial processing of glucose modulates C. elegans lifespan and healthspan 94%
- Stress reactivity elicits a tissue-specific reduction in telomere length in ageing zebrafish (Danio rerio) 93%
- Transcriptome Profiles of Anopheles gambiae Harboring Natural Low-Level Plasmodium Infection Reveal Adaptive Advantages for the Mosquito 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.