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Comprehensive Analysis of the Human Urinary Peptidome Using Peptide Clustering Approach Reveals Age- and Gender-Specific Patterns.
2025-05-16
nephrology
Title + abstract only
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BackgroundThe human urine peptidome reflects physiological and pathological states, making it a valuable resource for biomarker discovery. However, endogenous peptides often exist as cascades of truncated variants, complicating comparative analyses. To address this, we developed a "peptide cluster" approach, grouping overlapping peptides into representative clusters for robust statistical evaluation. MethodsUrine samples from 55 healthy volunteers (23 males, 32 females) were analyzed via LC-MS/...
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