Parental age selection in C. elegans influences progeny stress resistance capacity

Van Camp, B. T.; Curran, S. P.

2025-05-06 physiology

10.1101/2025.04.30.651556 bioRxiv

Show abstract

With parental age rising around the globe, an increased understanding of the impact on health and longevity is needed. Here, we report how the continuous selection of the last progeny during the Caenorhabditis elegans reproductive span results in a diminishment of multiple age-related health measures. After more than fifty generations of late selection, progeny displayed diminished resistance to acute oxidative stress, disrupted partitioning of stored lipids, reduced movement capacity, and an overall shortening of lifespan. In contrast, starvation resistance was improved and late selection had negligible effects on developmental timing and total reproductive output that suggests a reduction in lifespan health to preserve reproductive capacity. The phenotypes of late selection are reminiscent of animals with activation of the cytoprotective transcription factor SKN-1 but are unlikely a result of a spontaneous genetic mutation. These findings suggest the existence of a homeostatic mechanism for bookmarking the temporal boundaries of the parental reproductive span that reshapes the way we think about parental age influencing offspring fitness.

Published in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences · training set

Matching journals

●Non-profit ◐University press ○Commercial

The top 5 journals account for 50% of the predicted probability mass.

Only show non-profit

GeroScience

○ 109 papers in training set

Top 0.1%

18.8%