Dietary amino acid manipulations in the common marmoset Callithrix jacchus impacts serum metabolites and FGF21 levels
Fujita, Y.; Ishibuchi, T.; Uematsu, A.; Hayashi, T.; Obata, F.
Show abstract
Restricting dietary protein intake has metabolic and physiological benefits for animals. Rodent studies have identified the involvement of a hormone fibroblast growth factor 21 (FGF21), which is upregulated by sensing amino acid scarcity. However, to what extent this mechanism is conserved in primates remains elusive. Using common marmosets Callithrix jacchus as a non-human primate model, we demonstrate a protocol for protein restriction and dietary amino acid manipulation. Low protein diet induces a decrease in blood urea nitrogen, altered plasma amino acid profiles, and an increase in plasma FGF21. Supplementation of purified amino acids to the diet suppresses plasma features of protein restriction. Our data provide a dietary intervention technique in marmosets and an insight into the evolutionarily conserved mechanism of FGF21 induction during protein restriction.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails 94%
- Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition 93%
- Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification 93%
Similar papers in this journal
- Differential and synergistic effects of low birth weight and Western diet on skeletal muscle vasculature, mitochondrial lipid metabolism and insulin signaling in male guinea pigs 94%
- The effects of chronic consumption of lipid-rich and delipidated bovine dairy milk on brown adipose tissue volume in wild-type mice 93%
- Impact of formate supplementation on body weight and plasma amino acids 93%
Similar papers in this journal
- Uncovering Shared and Tissue-Specific Molecular Adaptations to Intermittent Fasting in Liver, Brain, and Muscle 94%
- Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice 94%
- Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats 94%
Similar papers in this journal
- Metabolic impact of trans 10, cis 12-conjugated linoleic acid on pai transgenic mice 94%
- Caloric restriction increases levels of taurine in the intestine and stimulates taurine uptake by conjugation to glutathione 94%
- Establishing reliable blood biomarkers for trimethylamine N-oxide status in rodents: effects of oral choline challenge, dietary choline and fasting conditions 93%
Similar papers in this journal
- Molecular programming in utero modulates hepatic lipid metabolism and adult metabolic risk in obese mother offspring in a sex-specific manner 94%
- Adipose gene expression profiles reveal novel insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus) 92%
- Evaluation of Commercially Available Glucagon Receptor Antibodies and Glucagon Receptor Expression 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.