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Persistent Aerointolerant Gut Microbes and Butyrate Depletion in Severe Acute Malnutrition
2025-02-10
nutrition
Title + abstract only
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Severe acute malnutrition (SAM) constitutes the leading risk for childhood mortality worldwide. Butyrate, a critical metabolite for mucosal immunity produced by anaerobic gut microbes, has been found to be dramatically depleted in children experiencing fatal outcomes related to SAM. However, the association between butyrate depletion and gut microbiota alteration has not yet been fully explored. Here, we performed a large group-matched case-control study in children aged 0-59 months in Mali. We ...
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