Effect of Antibiotic and Steroid Treatment on Leptospirosis Outcomes: A Single-Center Retrospective Cohort Study in the Transcarpathian Region of Ukraine
Petakh, P.; Oksenych, V.; Poliak, M.; Poliak, I.; Kohutych, A.; Kamyshnyi, O.
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Leptospirosis presents a significant health challenge in the Transcarpathian region of Ukraine, with higher incidence rates and mortality compared to national averages. We conducted a retrospective cohort study to investigate the effects of antibiotic and steroid treatments on outcomes in leptospirosis patients. Our analysis of clinical and laboratory data from a single center revealed that dexamethasone showed significant effects on various clinical variables, as did investigated antibiotics. Particularly, direct bilirubin levels emerged as a strong predictor of death. These findings provide valuable insights for clinicians in managing leptospirosis, aiding in outcome prediction and treatment decision-making not only in the Transcarpathian region but globally.
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