Lysosomal Enzyme activity: Establishing Reference Intervals from Patient Data
Mordaunt, D. A.; Stark, S.; Fietz, M.; Fletcher, J.; Metz, M.
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ObjectivesTo develop reference intervals for leukocyte lysosomal enzymology. DesignStandards-based establishment of reference intervals by analysis of 7851 for 17 assays of 15 lysosomal enzymes in leukocyte and plasma (January 1985 through September 2013). MethodsReference intervals were calculated using MedCalc for Windows version 12.5 (MedCalc Software, Ostend, Belgium), according to the Clinical and Laboratory Standards Institute C-28A protocol (CSLI-C28A). Results and ConclusionEvidence based reference intervals are presented in tabular form for seventeen assays of fifteen lysosomal enzymes.
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