Childhood adverse life events and skeletal muscle mitochondrial function
Duchowny, K.; Marcinek, D. J.; Mau, T.; Diaz-Ramirez, L. G.; Lui, L.-Y.; Toledo, F. G. S.; Cawthon, P. M.; Hepple, R. T.; Kramer, P. A.; Newman, A. B.; Kritchevsky, S. B.; Cummings, S. C.; Coen, P. M.; Molina, A. J. A.
Show abstract
Social stress experienced in childhood is associated with adverse health later in life. Mitochondrial function has been implicated as a mechanism for how stressful life events "get under the skin" to influence physical wellbeing. Using data from the Study of Muscle, Mobility and Aging (n=879, 59% women), linear models examined whether adverse childhood events (i.e., physical abuse) were associated with two measures of skeletal muscle mitochondrial energetics in older adults: (1) maximal adenosine triphosphate production (ATPmax) and (2) maximal state 3 respiration (Max OXPHOS). Forty-five percent of the sample reported experiencing 1+ adverse childhood event. After adjustment, each additional event was associated with -0.07 SD (95% CI= - 0.12, -0.01) lower ATPmax. No association was observed with Max OXPHOS. Adverse childhood events are associated with lower ATP production in later life. Findings indicate that mitochondrial function may be a mechanism in understanding how early social stress influences health in later life.
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