Cholecalciferol improves cognitive impairment by amending impaired insulin signaling in sporadic Alzheimers Disease Rats
DAS, T. K.; Yong, E.; Hamid, M. R. W. A.
Show abstract
Alzheimers disease (AD) is the most common form of dementia and contributes to 50-70% of neurodegenerative brain diseases. AD has been associated with poor vitamin D nutrition, which is correlated with low mood and impaired cognitive performance in older people. The impact of vitamin D on the insulin signaling pathway in AD is not well known. Hence, this study was to explore the effects of cholecalciferol (Vitamin D3) on the expression of IRS-1, IRS-2, Akt, pAkt (Ser473), and GLUT3 in the sporadic AD rat model. The rats were induced to develop sporadic AD by intraperitoneal administration of Scopolamine. The downregulation expression of IRS-1, IRS-2, Akt, pAkt (Ser473) and GLUT3 may lead to impaired insulin signaling which is associated with the development of AD. All these data were compared to Saline-treated control rats. However, cholecalciferol treatment in AD rats may improve memory performance by increasing the expression of insulin signaling proteins and hence ameliorates impaired insulin signaling. All these data were compared to Scopolamine-induced AD rats and sunflower oil-treated rats. Therefore, cholecalciferol treatment may be an alternative approach for the treatment of AD.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway 96%
- Thermal cycling protects SH-SY5Y cells against hydrogen peroxide and -amyloid-induced cell injury through stress response mechanisms involving Akt pathway 96%
- Title-Effects of Catha Edulis Forsk on Spatial Cognition and correlation with serum electrolytes in Wild- type Male White Albino Rats 96%
Similar papers in this journal
- Thermal cycling-hyperthermia attenuates rotenone-induced cell injury in SH-SY5Y cells through heat-activated mechanisms 95%
- Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer's Disease Mice 94%
- Inhibitory effects of β-caryophyllene on Helicobacter pylori infection in vitro and in vivo 93%
Similar papers in this journal
- The combination of lipopolysaccharide and D-galactosamine administration show positive genotoxic effect in mice liver 95%
- Enhanced expression of Dystrophin, IGF-1, CD44 and MYH3 in plasma and skeletal muscles including Diaphragm of mdx mice after oral administration of Neu REFIX Beta 1,3-1,6 glucan 94%
- Effect of MIND Diet Intervention on Cognitive Performance and Brain Structure in Healthy Obese Women: A Randomized Controlled Trial 94%
Similar papers in this journal
- Effects of memantine and high dose vitamin D on gait in the APP/PS1 mouse model of Alzheimer's disease following vitamin D deprivation 94%
- Common molecular signatures between coronavirus infection and Alzheimer's disease reveal targets for drug development 94%
- Association of GLOD4 with Alzheimers Disease in Humans and Mice 93%
Similar papers in this journal
- Analysis of serum trace elements, macro-minerals, antioxidants, malondialdehyde and immunoglobulins in seborrheic dermatitis patients: A case-control investigation 96%
- A small H2O-soluble ingredient of royal jelly lower cholesterol levels in liver cells by suppressing squalene epoxidase 95%
- Enhancing NADPH to Restore Redox Homeostasis and Lysosomal Function in G6PD-Deficient Microglia 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.