Association of IL-6 -174G/C and IL-10- 1082G/A Polymorphisms and Risk of Chronicity of Hepatitis B Infection in Sudanese End Stage Renal Disease Patients

BackgroundOvert hepatitis B virus (HBV) infection is defined as infection with detectable surface antigen (HBsAg) in patients blood. End stage renal disease (ESRD) patients who are on maintenance hemodialysis (HD) are considered to be strong candidates for HBV infection due to prolonged vascular access via HD procedure. In addition, the differences in host immune response can be one of the reasons for the various clinical presentations of HBV infection. Polymorphisms of genes encoding the pro-inflammatory and anti-inflammatory cytokines, which are responsible for regulation of the immune response, can affect the clinical presentation of the infection. Particularly, the polymorphisms of the genes encoding cytokines such as interleukin 6 (IL6) and interleukin 10 (IL10). AimThis current study aimed to compare serum levels and allelic variant of IL-6 -174G/C and IL-10- 1082G/A polymorphisms in patients with overt hepatitis B and end stage renal disease hepatitis B patients in Khartoum State- Sudan. MethodCase control study has been conducted to detect the IL-6 -174G/C and IL-10- 1082G/A polymorphisms using SSP-PCR and serum level of IL6 and IL10 using ELISA in 68 from Hepatitis B patient (37 overt hepatitis B patients and 31 end stage renal disease hepatitis B patients ResultThe result showed that there was no statistically difference in IL6 (174G/C) and IL10 (1082G/A) Allelic frequencies (P. value = .738, .194 respectively), Serum level (P. value = 0.36, .179 respectively) between two groups. In addition there is no significant correlation between the IL6 (174G/C) and IL10 (1082G/A) and serum level in study groups. ConclusionThe Allelic Variant of IL-6 -174G/C and IL-10- 1082G/A Polymorphisms and serum levels could not play apart in complication of hepatitis B in end stage renal disease patients.