Back

LINC01184 is highly expressed and functions as a tumor-promotive factor in hepatocellular carcinoma

Zhang, Q.; Yan, L.; Chen, J.; Liu, L.

2022-10-11 cancer biology
10.1101/2022.10.09.511516 bioRxiv
Show abstract

The expression and function of LINC01184 in hepatocellular carcinoma are unknown. We analyzed the changes in LINC01184 expression in hepatocellular carcinoma using public data, and also analyzed the relationship between LINC01184 and patient prognosis. In vitro, we investigated the effect of LINC01184 on HCC cell growth using cell activity analysis, clone formation analysis, and regulatory death analysis. We also explored the effect of LINC01184 on HCC cell migration using transwell analysis and scratch assay. We found that LINC01184 was significantly highly expressed in hepatocellular carcinoma tissues. Patients with high LINC01184 levels had poorer overall survival and disease-free survival. knockdown of LINC01184 in HUH7 and PLC/PRF/5 cells inhibited cell proliferation and induced regulatory death. Down-regulation of LINC01184 also leads to a reduction in the migratory capacity of cells. In conclusion, LINC01184 may become a biomarker or a new therapeutic target for HCC.

Matching journals

The top 12 journals account for 50% of the predicted probability mass.

1
PLOS ONE
● 5266 papers in training set
Top 16%
11.9%
Similar papers in this journal
2
Frontiers in Oncology
○ 103 papers in training set
Top 0.6%
5.5%
Similar papers in this journal
3
Aging
○ 75 papers in training set
Top 0.2%
5.2%
Similar papers in this journal
4
PeerJ
◐ 308 papers in training set
Top 1%
4.4%
Similar papers in this journal
5
Gene
○ 46 papers in training set
Top 0.3%
3.5%
Similar papers in this journal
6
RNA Biology
○ 78 papers in training set
Top 0.3%
3.2%
7
Biochemistry and Biophysics Reports
○ 30 papers in training set
Top 0.1%
3.2%
8
BMC Cancer
○ 67 papers in training set
Top 0.6%
3.2%
9
Scientific Reports
○ 3612 papers in training set
Top 38%
2.6%
10
Biochemical and Biophysical Research Communications
○ 84 papers in training set
Top 0.5%
2.6%
11
International Journal of Molecular Sciences
○ 494 papers in training set
Top 5%
2.4%
12
Heliyon
○ 152 papers in training set
Top 2%
2.4%
50% of probability mass above
13
Molecular Biology Reports
○ 21 papers in training set
Top 0.3%
2.4%
14
Frontiers in Genetics
○ 230 papers in training set
Top 2%
2.1%
15
Translational Oncology
○ 21 papers in training set
Top 0.3%
2.1%
16
eLife
● 5828 papers in training set
Top 45%
2.1%
17
Cancers
○ 213 papers in training set
Top 3%
1.9%
18
Cancer Medicine
○ 26 papers in training set
Top 0.5%
1.7%
19
Biomedicines
○ 67 papers in training set
Top 1%
1.7%
20
Cell Death & Disease
147 papers in training set
Top 2%
1.6%
21
Computational Biology and Chemistry
○ 28 papers in training set
Top 0.6%
1.3%
22
Life Sciences
○ 27 papers in training set
Top 0.6%
1.3%
23
FEBS Open Bio
○ 31 papers in training set
Top 0.5%
1.1%
24
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
○ 26 papers in training set
Top 0.5%
1.1%
25
BioMed Research International
○ 28 papers in training set
Top 1%
1.1%
26
Molecular and Cellular Biology
○ 47 papers in training set
Top 0.6%
1.1%
27
Journal of Translational Medicine
○ 57 papers in training set
Top 2%
1.0%
28
Medicine
○ 31 papers in training set
Top 1%
1.0%
29
Bioscience Reports
● 27 papers in training set
Top 1%
0.9%
30
Gene Reports
○ 14 papers in training set
Top 0.7%
0.8%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.