CD47 as a potential biomarker for the early diagnosis of severe COVID-19
McLaughlin, K.-M.; Bojkova, D.; Bechtel, M.; Kandler, J.; Reus, P.; Le, T.; Wagner, J. U.; Ciesek, S.; Wass, M. N.; Michaelis, M.; Cinatl, J. N.
Show abstract
The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Most SARS-CoV-2 infections are mild or even asymptomatic. However, a small fraction of infected individuals develops severe, life-threatening disease, which is caused by an uncontrolled immune response resulting in hyperinflammation. Antiviral interventions are only effective prior to the onset of hyperinflammation. Hence, biomarkers are needed for the early identification and treatment of high-risk patients. Here, we show in a range of model systems and data from post mortem samples that SARS-CoV-2 infection results in increased levels of CD47, which is known to mediate immune escape in cancer and virus-infected cells. Systematic literature searches also indicated that known risk factors such as older age and diabetes are associated with increased CD47 levels. High CD47 levels contribute to vascular disease, vasoconstriction, and hypertension, conditions which may predispose SARS-CoV-2-infected individuals to COVID-19-related complications such as pulmonary hypertension, lung fibrosis, myocardial injury, stroke, and acute kidney injury. Hence, CD47 is a candidate biomarker for severe COVID-19. Further research will have to show whether CD47 is a reliable diagnostic marker for the early identification of COVID-19 patients requiring antiviral therapy.
Matching journals
The top 11 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Inflammatory and immune markers in HIV-infected older adults on long-term antiretroviral therapy: persistent elevation of sCD14 and of proinflammatory effector memory T cells 93%
- Age-related changes in human skeletal muscle transcriptome and proteome are moreaffected by chronic inflammation and physical inactivity than primary aging 93%
- Telomerase Depletion Accelerates Ageing Of The Zebrafish Brain 93%
Similar papers in this journal
- SenolyticSynergy: An Attention-Based Network for Discovering Novel Senolytic Combinations via Human Aging Genomics 92%
- Genetic Networks of Alzheimer’s Disease, Aging and Longevity in Humans 92%
- Biology of healthy aging: Biological hallmarks of stress resistance-related and unrelated to longevity in humans 91%
Similar papers in this journal
- Donor-derived airway ALI model for high-throughput screening of antiviral combinations with concurrent analysis of antiviral efficacy and epithelial toxicity using ciliR 87%
- Asthma exacerbations and eosinophilia in the UK Biobank: a Genome-Wide Association Study 87%
- Shared genetic risk factors and their implications for treatment of IPF and systemic hypertension 86%
Similar papers in this journal
- Metformin alleviates aging-associated cellular senescence of human adipose stem cells and derived adipocytes 92%
- The HPA stress axis shapes aging rates in long-lived, social mole-rats 92%
- Single-Cell Transcriptomics Identifies Dysregulated Metabolic Programs of Aging Alveolar Progenitor Cells in Lung Fibrosis 91%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.