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A New Hematological Prognostic Index For Covid-19 Severity

A. Hammadi, A.; Al Jubouri, A. M.; Ahmed, G.; H. Hayyawi, A.; Kareem, K.; Gorial, F. I.; Waheeb Salman, M.; Ghanim, M.; F. Jameel, B.; Jawad, A. M.; Abbas, H. M.; Al-Gharawi, A. A.; Al-shareef, J. I.; Ali, C. L.; Nasser, K. F.; Y. Abdulrazaq, M.

2021-02-19 infectious diseases
10.1101/2021.02.11.21251285 medRxiv
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Backgroundsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or Covid-19 is a nationwide public health emergency with significant impact on human life. ObjectiveTo develop a new simple hematological prognostic index for Covid-19 severity state. Patients and methodsThis observational cross sectional study was conducted on 250 patients with Covid-19 disease. Age, gender, and severity of Covid -19 were recorded. Complete blood count and lactate dehydrogenase were measured. New index: COVID-19 severity-Iraqi-index = CSI index to predict COVID-19 severity. CSI index is monocyte/lymphocyte absolute counts multiplied by LDH (lactate dehydrogenase)/upper normal reference laboratory range of LDH value. ResultsMean age of patients was 50.4 + 15.1 years. Majority of patients were Males 148 (59.2%)..Most of patients were in stage 2 and 3 (> 94%). There was a significant difference between means of White Blood Cells, lymphocytes and Monocytes among the different stages of the disease (P = 0.0001, 0.036, 0.012). There was a significant moderate correlation between the prognostic index and the stage of the disease (r=0.41, p=0.0001). ConclusionsCSI index is a new simple predictor of clinical outcome in patients with covid-19 during early stage of the disease.

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