Innate Immune Response Modulation and Resistance to SARS-CoV-2 infection: A Prospective Comparative Cohort Study in High Risk Healthcare Workers
Jaiswal, D. S. R.; Mehta, A.; Bhagwati, D. G.; Lakhchaura, M. R.; Aiyer, D. H.; Khamar, D. B. M.; Chakrabarti, D. S.
Show abstract
To evaluate ability of modulated innate immune response to provide resistance to development of symptomatic RT-PCR confirmed COVID-19, 96 inpatient front line health care workers (HCW) were cohorted in 1:2 ratio to receive TLR2 agonist (heat killed Mycobacterium w, Mw; n=32) as innate immune response modulator or observation (n=64). All were followed up for 100 days. The incidence of COVID-19 was 31 (32.3%) for the entire cohort, with only one developing COVID-19 in Mw group (3.1% vs 46.8%. protective efficacy - 93.33%, p=0.0001; 95% CI 53.3-99.1). Self-limiting local injection site reaction was the only side effect and was seen in 14 HCW. Findings from the study suggest the potential for providing resistance against novel pathogen like SARS-CoV-2 by modulating innate immune response.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Role of ivermectin in the prevention of COVID-19 infection among healthcare workers in India: A matched case-control study 95%
- Prevalence, characteristics, and predictors of Long COVID among diagnosed cases of COVID-19 93%
- Characteristics and outcome profile of Hospitalized African COVID-19 patients: The Ethiopian Context 93%
Similar papers in this journal
- Incidence of Severe Acute Respiratory Syndrome Coronavirus-2 infection among previously infected or vaccinated employees 91%
- COVID-19 Infection Among Healthcare Workers in a National Healthcare System: the Qatar Experience 91%
- Survival analysis of all critically ill patients with COVID-19 admitted to the main hospital in Mogadishu, Somalia, 30 March–12 June 2020: what interventions are proving effective? 90%
Similar papers in this journal
- Adverse events following COVID-19 virus vaccination in Japanese young population: The first cross-sectional study conducted by a questionnaire survey after the first-time-injection 93%
- Adverse events following COVID-19 vaccination in young Japanese people: A case-control study of the risk of systemic adverse events by a questionnaire surveyShort title: COVID-19 vaccine adverse events in young Japanese 92%
- Patients at risk of pulmonary fibrosis Post Covid-19: Epidemiology, pulmonary sequelaes and humoral response 90%
Similar papers in this journal
- Cumulative incidence of SARS-CoV-2 and associated risk factors among healthcare workers in the Eastern Cape, South Africa 93%
- Epidemiological And Clinical Characteristics Of COVID-19 Patients In Kenya 92%
- Antibody response in individuals affected with Sars-Cov-2 infection: temporal trends and qualitative and quantitative differences in symptomatic and asymptomatic subjects. A Cross Sectional Analysis. Ab-Covid Study 91%
Similar papers in this journal
- Randomized, double blind, placebo controlled, clinical trial to study co-administration of Ashwagandha on safety, immunogenicity, and protection with COVID-19 vaccine – A Study Protocol 91%
- Clinico epidemiological profile of Omicron variant of SARS CoV2 in Rajasthan 91%
- Jinhua Qinggan Granules for Nonhospitalized COVID-19 Patients: a Double-Blind, Placebo-Controlled, Randomized Controlled Trial 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.