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Communicating polygenic and non-genetic risk for atherosclerotic cardiovascular disease - An observational follow-up study
2020-09-18
genetic and genomic medicine
Title + abstract only
View on medRxiv
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BackgroundAlgorithms including both traditional risk factors and polygenic risk scores (PRS) can significantly improve prediction of atherosclerotic cardiovascular disease (ASCVD). However, the clinical benefit of adding PRS to clinical risk evaluation remains unclear. ObjectivesThe study evaluated the attitudes of 7,342 individuals (64% women, mean age 56 yrs) upon receiving personal genome-enhanced ASCVD risk information, and prospectively assessed the impact on the participants health behavi...
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