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Reversal of Epigenetic Age with Diet and Lifestyle in a Pilot Randomized Clinical Trial

2020-07-14 genetic and genomic medicine Title + abstract only
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Manipulations to set back biological age and extend lifespan in animal models are well established, and translation to humans has begun. The length of human life makes it impractical to evaluate results by plotting mortality curves, so surrogate markers of age have been suggested and, at present, the best established surrogates are DNA methylation clocks. Herein we report on a randomized, controlled clinical trial designed to be a first step in evaluating the effect of a diet and lifestyle inter...

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