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Energy Metabolizes in Male Bone Marrow Mesenchymal Stem Cells Aging Process

Chen, Y.; Wang, H.; Lu, X.; Zhao, J.; Yang, L.; Wang, Y.

2026-07-08 cell biology
10.64898/2026.06.17.732798 bioRxiv
Show abstract

Senescence human bone marrow mesenchymal stem cells (BMSCs), vulnerable to age-related defects, is poor in tissue regeneration. Cells in bone marrow accumulated senescent contributing to the development of metabolic energy regulation hold prospects for therapeutic advances. This study aimed to evaluate energy metabolic changes in male bone marrow mesenchymal stem cells senescence process. Our research established cell specific surface marker and enzymes expression level changes, as well as ECAR and OCR resonance. Notably, CD14, HLA-DRB1 and CD90 upregulated, glycolysis-related genes are increased, tricarboxylic acid cycle-related genes are decreased. We firstly identified links between time-dependent cell aging process and energy metabolism in BMSCs.

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