Clinico-pathologic characteristics, patterns of treatment and outcome of newly diagnosed Waldenstroms Macroglobulinemia- a single center real world retrospective analysis
Gupta, V.; Podder, D.; Saha, S.; Shah, B.; Ghosh, S.; Kumar, J.; Jacoby, A. P.; Nag, A.; Chattopadhyay, D.; Javed, R.; Rath, A.; Chakraborty, S.; Demde, R.; Vinarkar, S.; Parihar, M.; Zameer, L.; Mishra, D.; Chandy, M.; Nair, R.
Show abstract
Waldenstrom macroglobulinemia (WM) is a rare indolent neoplasm characterized by presence of [≥] 10% lymphoid cells in BM that exhibit plasmacytoid or plasma cell differentiation that secretes an IgM monoclonal protein. This is a retrospective analysis of 89 patients of WM that describes the clinical and laboratory characteristics, treatment patterns and outcome of patients of WM. The median age of the entire cophort was 66 years with male predominance (67.4%). Most common presentations were symptoms pertaining to anemia (77.5%) and constitutional symptoms (33.7%). Median bone marrow lymphoplasmacytic cells were 41%. Positivity for MYD88 and CXCR4 mutations were seen in 81.8% and 2.4% cases. BR was the most common regimen used (52.8%). Overall response rates were seen at 87.8%. Median overall survival, progression free survival and time to next treatment is 8.49 years, 2.15 years and 3.88 years. BR regimen was associated with highest event free survival.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Association of ABO blood group with COVID-19 severity, acute phase reactants and mortality 93%
- SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsets 92%
- Laboratory Biomarkers of COVID-19 Disease Severity and Outcome: Findings from a Developing Country 92%
Similar papers in this journal
- A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data 90%
- Delayed-Phase Thrombocytopenia in Patients of Coronavirus Disease 2019 (COVID-19) 89%
- Platelet dysfunction in immune thrombocytopenia: finding clinical subsets with platelet phenotypes 89%
Similar papers in this journal
- CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma 91%
- Multiple Myeloma and SARS-CoV-2 Infection: Clinical Characteristics and Prognostic Factors of Inpatient Mortality 91%
- High WEE1 expression is independently linked to poor survival in multiple myeloma 90%
Similar papers in this journal
- Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning 91%
- Mice Mucosal Leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ cells response 90%
- Autoantibodies against eukaryotic translation elongation factor 1 delta (EEF1D) in two patients with autoimmune cerebellar ataxia 89%
Similar papers in this journal
- Blood transfusion in care of patients with Visceral Leishmaniasis: a review of practices in therapeutic efficacy studies 87%
- Molecular characterization of carbapenem resistant Klebsiella pneumoniae clinical isolates: Preliminary experience from a tertiary care teaching hospital in the Himalayas 87%
- The seroprevalence and trends of SARS-CoV-2 in Delhi, India: A repeated population-based seroepidemiological study 85%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.