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Aging Out of the Blue: Estimating and Calibrating Region-specific Epigenetic Clocks for a Blue Zone via SuperLearner

2026-03-03 epidemiology Title + abstract only
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Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from chronological age. However, standard clocks are typically trained on large, heterogeneous datasets, reflecting average population trends rather than region-specific dynamics. Using data from the Costa Rican Longevity and Health...

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