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A network-based atlas of human skeletal muscle aging
2026-02-17
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
Skeletal muscle metabolic and physical capacities are influenced by both genetics and load status and decline with age. Recent advances in sequencing have detailed cell types at unprecedented detail; yet these approaches do not scale to adequately model human muscle physiological heterogeneity. We produced a powerful resource for ageing studies, including consistent deep transcriptomic profiles of 1,675 human muscle biopsies ([~]28,000 genes per profile) and multiple single-cell spatial transcri...
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