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Alcohol Consumption and ALDH2 Polymorphism Jointly Modify the Association Between HDL Cholesterol and Coronary Artery Calcium Score in Older Adults

2026-02-03 epidemiology Title + abstract only
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ImportanceThe association between high-density lipoprotein cholesterol (HDL-C) and coronary artery calcium (CAC) burden remains unclear, and the potential modifying effects of lifestyle and genetic factors are not well characterized. ObjectiveTo clarify the relationship between HDL-C and CAC scores in older adults and examine whether alcohol consumption and the ALDH2 rs671 genetic variant modify this association. Design, Setting, and ParticipantsRetrospective analysis of 819 community-dwelling...

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