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Sex differences in LDL-C genetic architecture and statin efficacy in All of Us
2026-01-28
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
Low-density lipoprotein cholesterol (LDL-C) is a well-established and modifiable risk factor for cardiovascular diseases (CVDs), which has been the leading cause of mortality among women and men in the United States since 1921. Despite research demonstrating sexually dimorphic symptom presentation of CVD, women remain underdiagnosed and undertreated for CVDs relative to men. Using genotype and phenotype data from the All of Us (AoU) Research Program, we examined sex-specific differences in LDL-C...
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