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A Novel Host Stool mRNA Extraction Method Improves Sensitivity of Detection for Colorectal Cancer and Precancerous Lesions

2026-01-22 gastroenterology Title + abstract only
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BACKGROUNDEarly detection of colorectal cancer (CRC) is essential for reducing disease-related mortality; however, the invasiveness and resource intensity of colonoscopy limit its widespread use in population screening. Although several non-invasive screening modalities are available, their sensitivity remains suboptimal, particularly for advanced precancerous lesions (APL). Stool-derived host RNA biomarkers represent a promising approach to improve screening performance. However, numerous techn...

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