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Plasma Proteomics and Sensitive Imaging Biomarkers of Vascular Brain Injury

2026-01-22 genetic and genomic medicine Title + abstract only
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Background and ObjectivesIdentifying proteomic biomarkers associated with neuroimaging endophenotypes of cerebrovascular dysfunction and generalized neurodegeneration may provide insights into pre-Alzheimer disease pathological processes. This study aims to examine a broad panel of circulating proteins in relation to two diffusion tensor imaging (DTI) measures:free water (FW) and peak width of skeletonized mean diffusivity (PSMD), which are sensitive indicators of early white matter injury. Met...

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