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The divergent effects of nicotinamide riboside and high-intensity exercise training on skeletal muscle epigenetic aging
2026-01-21
genetic and genomic medicine
Title + abstract only
View on medRxiv
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Aging is accompanied by a decline in physiological function and increased vulnerability to disease, with mitochondrial dysfunction and epigenetic alterations recognized as key hallmarks. Nicotinamide riboside (NR), a vitamin B3 precursor to NAD, and high-intensity interval training (HIIT) have both been proposed to ameliorate aging-related mitochondrial decline, but their effects on skeletal muscle epigenetic aging are not fully elucidated. Here, we assessed the impact of 5-month NR supplementat...
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