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Rethinking Prenatal Folate Assessment: Maternal Folate Receptor Autoantibodies and Child Neurodevelopment
2026-01-16
public and global health
Title + abstract only
View on medRxiv
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Folic acid supplementation during pregnancy is established for preventing neural tube defects, yet its broader neurodevelopmental benefits remain inconsistently observed. Folate receptor autoantibodies (FRAA) may disrupt folate transport, but population evidence is lacking. In a prospective cohort of 3,006 mother-child pairs from the Shanghai Birth Cohort, we precisely quantified maternal red blood cell 5-methyltetrahydrofolate (active folate) and FRAA levels in early pregnancy. We found that hi...
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