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Peripheral blood profiles reflecting progenitor lineage balance predict treatment response in chronic myeloid leukemia
2026-01-21
hematology
Title + abstract only
View on medRxiv
Show abstract
Early achievement of deep remission improves patients outcome in chronic myeloid leukemia (CML) treatment, highlighting the need for predictive indicators before therapy initiation. This study aimed to develop a tool to predict CML treatment responses to guide optimal therapy selection. Using hierarchical clustering of complete blood count (CBC) data at diagnosis, patients were stratified into two clusters. Patients in Cluster 1 had higher BCR::ABL1IS mRNA levels at 3 and 6 months post-treatment...
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