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Hemispheric Asymmetry Defines Brain Aging: Five Reproducible NMF Modes Linked to Sex, Lifestyle, Transdiagnostic Genetic Risk, and Molecular Pathways

2025-12-29 geriatric medicine Title + abstract only
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Population aging heightens the burden of cognitive decline and brain disorders, yet trajectories of brain aging vary widely across individuals. Because the human brain is intrinsically lateralized, age-related shifts in hemispheric asymmetry may reveal latent aging subtypes that are masked by bilateral averages. Here, we derived reproducible and interpretable asymmetry-based brain-aging modes and validated their behavioral, genetic, and molecular signatures. Using UK Biobank MRI, we computed co...

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