Evidence of Accumulating Neurophysiologic Dysfunction in Persistent Post-COVID Fatigue
Germann, M.; Maffitt, N. J.; Burton, O. A.; Ashhad, A.; Baker, A. M. E.; Zaaimi, B.; Ng, W.-F.; Soteropoulos, D. S.; Baker, S. N.; Baker, M. R.
Show abstract
A major consequence of the COVID-19 pandemic has been the emergence of post-COVID syndrome (PCS), and more specifically, post-COVID fatigue (pCF), with an estimated prevalence of [~]2%. We previously showed that, compared to healthy controls, people with pCF exhibit changes in muscle physiology, cortical circuitry, and autonomic function. Here we present results from a cohort of people with pCF (N=145), between 12 weeks and 45 months post-infection. We report self-perception of fatigue; objective measures of cortical circuits via transcranial magnetic stimulation and reaction time tasks; peripheral muscle fatigue; and autonomic function such as heart rate variability. Those with pCF persisting >200 days had significantly more fatigue and showed increased cortical excitability, slower reaction times and increased peripheral muscle fatigue compared to those with <200 days of pCF . In pCF, if there is no spontaneous recovery, fatigue worsens, and patients continue to accumulate significant neurophysiologic abnormalities.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Increased sensorimotor noise in Tourette syndrome 92%
- Beta Burst-Driven Adaptive Deep Brain Stimulation Improves Gait Impairment and Freezing of Gait in Parkinson’s Disease 91%
- Information processing speed modulation by electrical brain stimulation in multiple sclerosis: Towards individually-tailored protocols 91%
Similar papers in this journal
- Recovery of Neurophysiological Measures in Post-COVID Fatigue – a 12-month Longitudinal Follow-up Study 98%
- Opposite white matter abnormalities in post-infectious vs. gradual onset chronic fatigue syndrome revealed by diffusion MRI 93%
- Evaluating phasic transcutaneous vagus nerve stimulation (taVNS) with pupil dilation: the importance of stimulation intensity and sensory perception 92%
Similar papers in this journal
- Effect of transcranial direct current stimulation on post-stroke fatigue 94%
- Comprehensive transcriptomic analysis shows disturbed calcium homeostasis and deregulation of T lymphocyte apoptosis in inclusion body myositis 92%
- Interval timing and midfrontal delta oscillations are impaired in Parkinson’s disease patients with freezing of gait 90%
Similar papers in this journal
- Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome 93%
- Developing Interferon-β as a safe in-vivo experimental-medicine model of human inflammation. 91%
- Immune activation and immune-associated neurotoxicity in Long-COVID: A systematic review and meta-analysis of 82 studies comprising 58 cytokines/chemokines/growth factors. 91%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.