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Raising the alarm: Endotoxin contamination in lithium heparin tubes is a threat to cell-based assay reliability
2025-12-22
medical education
Title + abstract only
View on medRxiv
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ObjectiveIn vitro cytokine release assays are essential tools in immunological research, yet their reliability can be influenced by various pre-analytical factors. This study was initiated to investigate the potential impact of lithium heparin whole blood collection tubes from different manufacturers on assay performance. The objective of this work is to urge the scientific community to consider whole blood collection tubes as a significant and often underestimated source of variability in cell-...
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