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An Evaluation of Age-varying Genetic Effects underlying Body-mass Index and Blood Pressure in the UK Biobank

2025-12-17 genetic and genomic medicine Title + abstract only
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Genome-wide association studies (GWAS) are conventionally conducted in cohorts spanning a wide age-range. These studies typically assume that genetic associations are constant across different ages. Some traits, however, may have age-varying genetic associations. This has implications for the interpretation of genetic effects derived in downstream applications, such as Mendelian randomization (MR) analyses. In this study we conducted a series of age-stratified GWAS on individuals aged 40-69 year...

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