Accelerometry-Measured Physical Activity Predicts Dementia Onset in a National Cohort of Older Adults
Ko, M.; Huang, C.-H. S.; Brown, K. J.; Vintch, K.; Shutes-David, A.; Wilson, K.; Seto, E.; Tsuang, D. W.
Show abstract
Identifying scalable, objective markers of dementia risk is essential for early prevention and intervention. Physical activity is a key modifiable risk factor, yet evidence from device-based measures in representative populations remains limited. Using nationally representative data from the National Health and Aging Trends Study (NHATS), we examined whether wrist-worn accelerometry predicts incident dementia in a cohort of 562 participants aged [≥] 65 years without dementia at baseline. Over one year of follow-up, higher physical activity levels were associated with lower risk of incident dementia (OR = 0.66, 95% CI [0.55 - 0.79]), even after adjusting for age, gender, and comorbidities (OR = 0.68, 95% CI [0.57 - 0.82]). Receiver operating characteristics (ROC) analyses indicate that accelerometry modestly outperforms self-reported physical capacity in predicting dementia onset. These findings support the use of wearable-derived activity metrics as a potential digital biomarker for dementia risk stratification in population and clinical settings.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Attenuated cognitive decline in community-dwelling older adults with higher plasma adropin concentrations 93%
- Complementary value of molecular, phenotypic and functional aging biomarkers in dementia prediction 92%
- Topographical differences in white matter hyperintensity burden and cognition in aging, MCI, and AD 92%
Similar papers in this journal
- Ageing and Dementia: Age-Period-Cohort Effects of Policy Intervention in England, 2006-2016 94%
- Deconditioning in people living with dementia during the COVID-19 pandemic: findings from the Promoting Activity, Independence and Stability in Early Dementia (PrAISED) process evaluation 93%
- Patterns of Physical Activity Over Time in Older Patients Rehabilitating after Hip Fracture Surgery: A Preliminary Study 93%
Similar papers in this journal
- The impact of outdoor walking interventions on frailty among older adults with mobility limitations: findings from the Getting Older Adults Outdoors (GO-OUT) study 95%
- Impact of the COVID-19 pandemic on cognitive function in Japanese community-dwelling older adults in a class for preventing cognitive decline 95%
- Large household reduces dementia mortality 94%