Establishment of the trans-resveratrol-induced mouse pulmonary fibrosis model and its comparison with the bleomycin-induced model
Chen, Y.; Zong, C.; Sheng, C.; Chang, H.; Wang, S.; Zhao, H.; Liu, S.; Zhang, Q.; Dong, R.; Ge, D.; Yu, X.; Li, L.
Show abstract
Pulmonary fibrosis (PF) is a progressive, fatal disease, and its pathogenic mechanism has not yet been identified. The bleomycin (BLM)-induced animal model has several shortcomings that cannot be overcome. We accidentally found that the continuous oral administration of trans-resveratrol (TR) at levels above the prescribed dose can induce PF within a certain period of time, and this model can be successfully replicated in mice, as indicated by the hydroxyproline (HYP) test and pathological analysis. The TR model requires no anesthesia or surgery and thus causes less damage to mice than the BLM model. The progress of fibrosis in the TR model was slow but progressed steadily compared with the BLM model, and the TR model was more comparable to human PF. Although the pathogenesis is not understood, the TR-induced PF model indicated that there may be a close relationship between PF and tumors and antitumor drugs, which requires further exploration.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl/6 mice: Relevance to inflammatory markers in human bronchial epithelial cells 96%
- Recombinant human soluble thrombomodulin is associated with attenuation of sepsis-induced renal impairment by inhibition of extracellular histone release 95%
- Bioinformatics analyses and experimental validation of ferroptosis-related genes in bronchopulmonary dysplasia pathogenesis 95%
Similar papers in this journal
- The combination of lipopolysaccharide and D-galactosamine administration show positive genotoxic effect in mice liver 96%
- Effects of different environmental intervention durations on the intestinal mucosal barrier and the brain-gut axis in rats with colorectal cancer 95%
- Vitamin A supplement after neonatal Streptococcus pneumoniae pneumonia alters CD4+T cell subset and inhibits allergic asthma in mice model 94%
Similar papers in this journal
- Effect of prophylactic use of intra-nasal oil formulations in the hamster model of Covid-19 96%
- The mitochondrial deubiquitinase USP30 regulates AKT/mTOR signaling 93%
- The cytoprotective role of antioxidants in mammalian cells under rapidly varying temperature, pressure and UV conditions during stratospheric balloon campaign 91%
Similar papers in this journal
- Schistosoma Japonicum infection in Treg-specific USP21 knock-out mice 92%
- Ion transport modulators differentially modulate inflammatory responses in THP-1 derived macrophages 92%
- Myeloperoxidase and Eosinophil Peroxidase Inhibit the in vitro Endotoxin Activities of Lipopolysaccharide (LPS) and Lipid A and Increase Survival in an in vivo Mouse LPS LD90 model 91%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.