Saliva Cytokines in Adult Patients with Different Tooth Caries Intensity

AimTo study the saliva content and correlation with the intensity of caries of proinflammatory cytokines IL-1{beta}, IL-6, IL-8 and anti-inflammatory cytokines IL-4 and IL-10. Methodology33 patients aged 18 to 30 years were divided into 3 groups - a group of patients without caries, a group with compensated caries at the index value the intensity of caries of the DMF (decay/ missing/ filled) is less than 5.0 and the group with decompensated caries with a DMF index value of more than 5.0. ResultsIt was found that both compensated and decompensated caries statistically significantly reduced the concentration of anti-inflammatory cytokine IL-4. With compensated caries, a significant decrease in the content of pro-inflammatory cytokine IL-8 had a direct positive correlation with the concentration of anti-inflammatory cytokine IL-10 in saliva. The DMF index was in negative correlation with the concentration of IL-6 in saliva. With decompensated caries, there was a significant increase in the content of the proinflammatory cytokine IL-1{beta} in saliva, which exceeded the same indicator in other groups by 3 or more times. ConclusionThe concentration of pro-inflammatory cytokines IL-6 and IL-8 in saliva had a pronounced postitive correlation with the concentration of anti-inflammatory cytokine IL-10.