GLP1 receptor agonists attenuate systemic inflammation through microbiota mediated enrichment of Faecalibacterium prausnitzii and Roseburia spp
Tanaka, H.; Nakamura, Y.; Fujimoto, A.; Sato, K.; Suzuki, M.
Show abstract
This study investigated the comparative anti-inflammatory effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and nonsteroidal anti-inflammatory drugs (NSAIDs), with a particular focus on microbiota-mediated mechanisms. A total of 120 participants were enrolled, including a GLP-1 RA group (n = 60) and an NSAID control group (n = 60). After 12 weeks of treatment, the GLP-1 RA group showed significant reductions in systemic inflammatory markers, with C-reactive protein (CRP) decreasing from 4.3 {+/-} 0.6 to 2.1 {+/-} 0.4 mg/L (p < 0.01), interleukin-6 (IL-6) decreasing from 3.6 {+/-} 0.5 to 1.8 {+/-} 0.3 pg/mL (p < 0.01), and tumor necrosis factor- (TNF-) decreasing from 18.2 {+/-} 1.5 to 12.5 {+/-} 1.2 pg/mL (p < 0.05). In contrast, the NSAID group exhibited only modest reductions in these markers without achieving normalization. Microbiome analysis revealed a significant post-treatment enrichment of Faecalibacterium prausnitzii (r = -0.46 with CRP, p < 0.001) and Roseburia spp. (r = -0.39 with CRP, p < 0.01) in the GLP-1 RA group, whereas NSAIDs showed no comparable effect. These findings establish a novel mechanistic link between incretin-based therapies and host immune homeostasis, highlighting the potential of GLP-1 RAs as systemic anti-inflammatory agents beyond their metabolic benefits.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A Mediterranean-like fat blend protects against the development of severe colitis in the mucin-2 deficient murine model 94%
- An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors 94%
- Enhancing Recovery from Gut Microbiome Dysbiosis and Alleviating DSS-Induced Colitis in Mice with a Consortium of Rare Short-Chain Fatty Acid-Producing Bacteria 94%
Similar papers in this journal
- Fructose malabsorption induces dysbiosis and increases anxiety in Human and animal models 93%
- Perinatal Morphine Exposure Induces Long-Term Changes in the Intestinal Microbiota of Male and Female Rats 92%
- Early-Life Gut Inflammation Drives Sex-Dependent Shifts in the Microbiome-Endocrine-Brain Axis 92%
Similar papers in this journal
- Gut bacterial metabolite Urolithin A (UA) mitigates Ca2+ 1 entry inT cells by regulating miR-10a-5p 94%
- Secondary bile acid lithocholic acid ameliorates colitis-like inflammation in a human intestine-on-chip system 93%
- Identification of omega-3 oxylipins in human milk-derived extracellular vesicles with pro-resolutive actions in gastrointestinal inflammation. 92%
Similar papers in this journal
- Longitudinal gut microbial signals are associated with weight loss: insights from a digital therapeutics program 93%
- Clinical Trial of a Probiotic and Herbal Supplement for Lung and Gut Health 92%
- The Biochemical Effects of Carotenoids in Orange Carrots on the Colonic Proteome in a Mouse Model of Diet-induced Obesity 92%
Similar papers in this journal
- Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma 94%
- Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition 93%
- Multiple nutritional and gut microbial factors associated with allergic rhinitis: the Hitachi Health Study 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.