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A new NHGRI Sample Repository for Human Genetic Research collection of induced pluripotent stem cell lines.

Pozner, T.; Grandizio, C.; Mitchell, M. W.; Turan, N.; Scheinfeldt, L.

2025-08-06 cell biology
10.1101/2025.08.05.668740 bioRxiv
Show abstract

We describe here a new NHGRI Sample Repository for Human Genetic Research collection of induced pluripotent stem cell (iPSC) lines reprogrammed from whole blood derived peripheral blood mononuclear cells (PBMCs). PBMCs were reprogrammed using Sendai viral vectors carrying transcription factors OCT4, SOX2, KLF4, and c-MYC. All iPSC lines exhibit a normal karyotype, express common stemness and pluripotency markers, and demonstrate the ability to differentiate into cell types representing all three germ layers. This iPSC collection (n=7) will have accompanying public, near telomere to telomere genomic data through the Human Pangenome Reference Consortium, and provides an invaluable new in vitro resource for studying common genetic and genomic variation and its functional implications.

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