Effectiveness of non-pharmacological Interventions For Fatigue in Long term conditions (EIFFEL) - systematic review and network meta-analysis

ObjectiveTo assess the clinical effectiveness of non-pharmacological interventions for fatigue in adults with long term medical conditions. DesignSystematic review and network meta-analysis Data sourcesAll searches were performed on the following databases: MEDLINE, Embase, CINAHL, APA PsycINFO, Web of Science Core Collection and the Cochrane Central Register of Controlled Trials. MethodsScreening of eligible studies was performed independently and in duplicate, with data extraction and risk of bias assessments conducted by one of two reviewers and validated by the other. Random effects network meta-analyses were conducted for the primary analyses. The primary outcome was self-reported fatigue at end of treatment, short term (up to 3 months after end of treatment) and long term (more than 3 months). The primary network meta-analyses pooled data from all conditions for each time point; a secondary analysis was carried out for separate condition categories. Three rounds of focus groups of people with lived experience of fatigue informed decisions about aggregating data across interventions and conditions, and interpretation of the findings. Eligibility criteria for selecting studiesRandomised controlled trials of non-pharmacological interventions for fatigue in long term medical conditions where fatigue was either a criterion for inclusion, the primary target of the intervention, or the primary or co-primary outcome. We excluded studies of post-infectious, post-traumatic, cancer-related or idiopathic fatigue and limited inclusion to European-style healthcare systems. Results88 randomised controlled trials were included, comprising 6636 participants for end of treatment analyses, 1849 (short term) and 2322 (long term), allocated to one of 27 interventions. The most common condition studied was multiple sclerosis (51 studies). Compared to usual care, cognitive behavioural therapy (CBT)-based interventions showed statistically significant reductions in fatigue at end of treatment (standardised mean difference -0.63, 95% credible interval (CrI) -0.87 to -0.4, 17 studies) and long term follow up (-0.4, -0.63 to -0.21,9 studies). Physical activity promotion showed significant reduction in fatigue at all three time points: end of treatment (-0.32, -0.62 to -0.01,7 studies), short term (-0.51, -0.84 to -0.17, 1 study) and long term (-0.52, -0.86 to -0.18, 2 studies). Self-management focusing on energy conservation showed no statistically significant benefit at end of treatment (-0.2, -0.52 to 0.12, 10 studies), short term (-0.13, -0.51 to 0.25, 7 studies) or long term (-0.42, -0.9 to 0.09, 3 studies). ConclusionsInterventions which support individuals to increase physical activity or that are based on cognitive behavioural are effective in reducing fatigue in people with long-term medical conditions. The strength of the evidence for these is moderate to low. Although there are relatively few studies in any condition other than multiple sclerosis, the magnitude of effect appears similar across different conditions. Systematic review registrationPROSPERO CRD42023440141