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Bioinformatic Screen with Clinical Validation for the Identification of Novel Stool Based mRNA Biomarkers for the Detection of Colorectal Lesions Including Advanced Precancerous Lesions

2025-07-18 gastroenterology Title + abstract only
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Messenger RNA (mRNA) stool based biomarkers represent a promising approach for the diagnosis of colorectal cancer (CRC) and advanced precancerous lesions (AA). But it is unclear which mRNA biomarkers have the most clinical utility. This study aims to partially fill this gap by performing an analysis which first ranks genes based on their expression profile in RNA-seq tissue datasets. The diagnostic performance of the top 20 ranked genes was then tested using 113 clinical samples (CRC N=33, AA N...

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