Perioperative Dynamics of Autoantibodies Against Neurotransmitter Receptors in Liver Surgery: A Secondary Analysis of the PHYDELIO Trial

2025-07-11 anesthesia Title + abstract only

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BackgroundPostoperative delirium (POD) is a common neurocognitive complication following major surgery, particularly in older adults and those undergoing liver resections. Neuroinflammatory mechanisms are considered central to its pathophysiology, yet molecular mediators remain poorly defined. Autoantibodies (aABs) targeting G protein-coupled receptors (GPCRs)--especially those relevant to neurotransmission--may contribute to POD by disrupting neuroimmune homeostasis. This study explored the per...