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Growth Differentiation Factor 15 Connects Stress and Ageing in a UK Biobank Cohort
2025-07-05
geriatric medicine
Title + abstract only
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BackgroundThe brain-body energy-conservation model proposes that signals from metabolically active senescent cells, including growth differentiation factor 15 (GDF15), prompt the brain to downregulate systemic energy expenditure, leading to functional decline. However, large-scale human studies testing this hypothesis are lacking. We examined whether circulating GDF15 is associated with physiological and cognitive ageing phenotypes and whether it mediates the relationship between psychological ...
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